When considering alternative treatments for depression, especially for those dealing with treatment-resistant depression, two common options are Spravato and ketamine infusions. Both are gaining attention in mental health care, but it’s important to understand their differences to find the most effective treatment.

What is Spravato?

Spravato is a nasal spray form of esketamine, which is a derivative of ketamine. Developed by Johnson & Johnson, Spravato has gained attention for its potential to act as a rapid-acting antidepressant, providing relief in hours rather than the weeks traditional antidepressants may require. It’s particularly designed for patients with treatment-resistant depression who have not found success with other depression treatment methods.

In clinical studies, Spravato has shown promising results, leading the FDA to approve it as an alternative depression treatment for those with severe depression that doesn’t respond to other medications. You can read more about the research and FDA approval process on Spravato research.

What are Ketamine Infusions?

Ketamine infusions, on the other hand, involve administering ketamine intravenously. Unlike Spravato, which is a specific form of ketamine, these infusions use the full ketamine compound. Ketamine has been used for decades as an anesthetic and pain reliever, but recent studies have discovered its effectiveness as a rapid-acting antidepressant for severe depression and other mood disorders.

Ketamine treatments are often sought after for their potential in psychedelic therapy, where the drug’s dissociative effects can provide a new perspective on ingrained thought patterns and emotional responses. These treatments have been particularly helpful for patients with treatment-resistant depression, offering relief where traditional therapies have failed.

Spravato vs. Ketamine: Which is Better?

Choosing between Spravato and ketamine largely depends on individual needs and the specifics of each case. Some patients may find Spravato more convenient, as it is administered via nasal spray under supervision and has a standardized dosing protocol. However, others may prefer the personalized nature of ketamine infusions, where the dosage can be adjusted based on the patient’s response.

There are also differences between Spravato’s and ketamine’s side effects. Spravato, being a derivative of ketamine, tends to have fewer side effects, but it is not without risks, including dizziness, dissociation and nausea. Ketamine side effects can be more pronounced, given the full potency of the drug, but many patients tolerate it well, especially when administered in a controlled, clinical setting.

The Role of Dissociative Drugs in Mental Health

Both Spravato and ketamine are classified as dissociative drugs, meaning they can create a sense of detachment from reality. While this may sound alarming, it is this very property that allows patients to step outside of their usual thought patterns, potentially leading to breakthroughs in their mental health treatment.

These treatments represent the cutting edge of mental health treatment options, offering hope to those who have struggled to find relief through traditional methods. If you or a loved one is dealing with treatment-resistant depression, exploring these options could be the key to finding a new path forward.

Conclusion: Making the Right Choice

The decision between Spravato treatment and ketamine infusions should be made in consultation with a healthcare provider who can assess your specific situation. If you’re ready to take the next step in overcoming depression, you can speak with our specialists today.

During October, call us at 877-635-8127 to receive a complimentary TMS session & consult!

For more information on how these treatments can help you overcome depression, visit our Spravato page.